Efficacy and Safety of Lixisenatide Once-Daily Morning or Evening Injections in Type 2 Diabetes Inadequately Controlled on Metformin (GetGoal-M)
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Semaglutide May Be Best For: Individuals who want a well-studied, FDA-approved medication with extensive long-term safety data Patients who prioritize cardiovascular risk reduction (supported by the SELECT trial) People seeking a medication with established insurance coverage pathways Individuals with moderate weight loss goals (10-15% of body weight) Patients who value the reassurance of a medication used by millions of people worldwide Retatrutide May Be Best For (Once Available): Individuals who need greater than 15-20% body weight loss Patients who have plateaued on semaglutide or tirzepatide People with significant metabolic dysfunction who may benefit from the glucagon receptors effects on liver fat and energy expenditure Individuals with MASH (metabolic dysfunction-associated steatohepatitis) given the glucagon receptors role in hepatic fat metabolism Patients willing to use a newer medication with less long-term safety data in exchange for potentially greater efficacy What to Expect During Treatment Starting Semaglutide Weeks 1-4: Starting dose of 0.25 mg weekly
And that fourth pathway, the amylin system, does not just add incremental benefit
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